Popeye domain-containing 1 is down-regulated in failing human hearts
نویسندگان
چکیده
منابع مشابه
Popeye domain-containing 1 is down-regulated in failing human hearts.
Congestive heart failure, a complex disease of heterogeneous etiology, involves alterations in the expression of multiple genes. The Popeye domain-containing (POPDC) family of three novel muscle-restricted genes (POPDC1-3) is evolutionarily conserved and developmentally regulated. In mice, POPDC1 has been shown to play an important role in skeletal and cardiac muscles subjected to injury or str...
متن کاملPopeye Domain Containing 1 (Popdc1/Bves) Is a Caveolae-Associated Protein Involved in Ischemia Tolerance
Popeye domain containing1 (Popdc1), also named Bves, is an evolutionary conserved membrane protein. Despite its high expression level in the heart little is known about its membrane localization and cardiac functions. The study examined the hypothesis that Popdc1 might be associated with the caveolae and play a role in myocardial ischemia tolerance. To address these issues, we analyzed hearts a...
متن کاملFailing Human Hearts
Background A variety of previous studies have demonstrated reduced diastolic potential and electrical activity in atrial specimens from patients with heart disease. Although K' channels play a major role in determining resting membrane potential and repolarization of the action potential, little is known about the effects of preexisting heart disease on human atrial K' channel activity. Methods...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2010
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2010.558